Table 1 Categories of biological functions and number of proteins identified in the extract from parotoids of the common toad Bufo bufo displaying particular functions
Function category | Biological function | No. of proteins |
|---|---|---|
1—Cell division & cell cycle regulation | Cell division, cell cycle cytokinesis, cell proliferation, cell cycle regulation/control/progression, cell growth control, mitotic cell cycle, mitosis regulation, DNA replication | 34 |
2—Cell differentiation & tissue development | Cell differentiation, angiogenesis, skeletal muscle tissue development, epidermis development, bone development, morphogenesis | 17 |
3—Cell migration | (Regulation of) cell migration | 8 |
4—Cell structure maintenance | Cytoskeleton organisation, microtubules structure, actin filament organisation, intermediate filament cytoskeleton organisation, mitochondrial genome maintenance, Golgi organisation, membrane structure, regulation of cell shape, blood vessel diameter maintenance, extracellular matrix assembly, cell adhesion | 24 |
5—Cell aging & apoptosis | Aging, apoptosis, programmed cell death (regulation) | 21 |
6—Signal transduction | Signal transduction, cell signalling (pathway) | 15 |
7—Metabolism | Biosynthesis, anabolism, catabolism, transcription and translation regulation, glycolysis, proteolysis, protein degradation, protein homeostasis, protein folding, protein ubiquitination, phosphorylation, intracellular pH reduction, cell motility, neurotropic and neuroprotective activity, regulation of heart rate, muscle contraction, wound healing, protein secretion, regulation of the blood coagulation cascade | 99 |
8—Transport | Intra- and extracellular transport, nuclear transport, ion and electron transport, protein transport, toxin transport, membrane fission, channel or molecule transporter | 24 |
9—Stress response | Stress response, response to hydrogen peroxide, oxidative stress, hypoxia tolerance, response to xenobiotic stimulus, proteolytic stress response, heat stress response, response to increased oxygen levels, cellular hypotonic response, cell redox homeostasis | 18 |
10—Immune response | Innate and adaptive immune response, allergic/inflammatory/antimicrobial response, cell response to interleukins (IL), regulation of macroautophagy | 20 |
11—DNA repair | DNA repair | 6 |