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Table 3 The effect of different drugs on the motility of the distal stomach

From: Enteric neuroanatomy and smooth muscle activity in the western diamondback rattlesnake (Crotalus atrox)

Drug

N (tissue/animal)

Tone Before (mN)

Tone After (mN)

p value

Ampl. Before (mN)

Ampl. After (mN)

p value

Freq. Before (1/min)

Freq. After (1/min)

p value

EFS contractile on before (mN)

EFS contractile on after (mN)

p value

Ach

11/7

7.8 [5.9/11.8]

8.8 [7.4/19.6]

0.002

1.6 [0.6/7.6]

14.1 [6.9/31.7]

0.031

0.4 ± 0.1

0.7 ± 0.1

0.01

   

Atropine

14/11

9.4 [7.2/10.8]

9.1 [6.4/10.1]

0.005

5.3 [3.0/12.2]

3.3 [2.0/9.6]

< 0.001

0.7 ± 0.1

0.6 ± 0.1

0.739

16.0 [6.2/34.9]

1.8 [0.0/4.7]

< 0.001

L-NAME

16/9

10.6 [4.7/14.6]

10.5 [6.6/13.4]

0.98

4.1 [2.0/10.6]

22.5 [7.9/35.5]

< 0.001

0.5 ± 0.3

0.6 ± 0.2

0.389

21.4 [8.6/37.4)

98.1 [62.9/119.2]

< 0.001

SNP

8/6

7.6 [5.5/12.0]

6.1 [3.6/8.6]

0.008

12.4 [5.5/15.2]

0.5 [0/1.7]

0.008

0.9 ± 0.1

0.5 ± 0.2

0.101

   

5-HT

7/4

6.2 [4.4/8.6]

7.1 [6.2/8.9]

0.016

1 [0/1.4]

3.5 [2.2/14.4]

0.016

0.6 ± 0.5

1 ± 0.2

0.0775

   

Dopamine

8/4

6.0 [3.7/8.3]

8.0 [4.7/9.7]

0.039

5.1 [0.4/6.6]

10.2 [1.8/13.4]

0.042

0.7 ± 0.3

0.9 ± 0.4

0.001

   

Domperidone

7/3

10.0 [8.8/14.1]

10.4 [7.9/14.0]

1

6.0 [4.4/8.0]

7.9 [4.8/12.0]

0.563

0.7 ± 0.2

0.7 ± 0.1

0.734

74.0 [33.6/92.9]

31.4 [19.0/81.7]

0.375

VIP

7/4

8.6 [7.4/11.0]

7.4 [6.3/9.8]

0.031

2.2 [0.3/7.9]

0.8 [0.4/2.2]

0.219

0.6 ± 0.1

0.5 ± 0.1

0.368

   

Suramin

9/4

12.8 [5.5/15.0]

12.6 [5.4/14.0]

0.359

8.0 [4.2/13.6]

11.9 [7.1/16.5]

0.031

0.7 ± 0.1

0.7 ± 0.1

0.341

22.8 [0.1/27.7]

16.3 [2.9/28.6]

0.938

Propranolol

9/8

5.0 [3.6/10.3]

5.6 [3.9/10.2]

0.359

5.5 [4.1/6.7]

6.0 [3.4/8.7]

0.359

0.7 ± 0.1

0.7 ± 0.1

0.526

35.2 [15.2/57.2]

45.1 [19.9/62.1

0.031

Isoproterenol

11/7

7.2 [6.2/10.4]

4.5 [3.3/6.4]

< 0.001

4.6 [2.9/9.1]

0.0 [0.0/2.1]

0.008

0.7 ± 0.1

0.4 ± 0.2

0.025

26.5 [8.8/74.0]

4.80 [2.2/10.0]

0.031

TTX

7/4

8.5 [8.3/13.1]

8.7 [8.1/12.2]

0.219

13.8 [3.1/30.5]

15.8 [10.2/26.7]

0.844

0.3 ± 0.1

0.4 ± 0.1

0.332

17.1 [8.6/64.4]

42.5 [3.0/55.3]

0.938

Lidocaine

8/6

10.8 [4.8/14]

18.9 [1.7/31.5]

0.021

4.4 [3.6/6.9)

5.9 [4.1/13.0]

0.742

0.6 ± 0.1

0.8 ± 0.1

0.012

1.9 [1.2/32.5]

0.0 [0.0/0.3]

0.004

Na-free Krebs sol

6/3

7.5 [3.9/12.0]

25.6 [19.3/33.7]

0.031

2.4 [1.0/3.9]

19.6 [6.9/25.8]

0.031

0.7 ± 0.2

1.1 ± 0.01

0.029

7.6 [4.3/10.6]

0.0 [0.0/0.6]

0.031

  1. Changes of the muscle tone, of the frequency and amplitude of spontaneous contractions, and of the response to EFS after the application of different drugs. Bold letters mean a significant effect
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Frontiers in Zoology

ISSN: 1742-9994