Fig. 1

Lipidomic from summer and winter brown bear serum. The winter and summer bear serum mixes were prepared as described (Supplementary Table S1). a: Total fatty acid (FA) concentration. b: Total n-6 and n-3 FA relative proportions of total lipids. c: Highest molar percent lipid species D: Molar percent of the n-3 family lipid species. e: Molar ratios of DHA/AA in summer and winter serum. Detailed lipidomic results are presented in Supplementary Tables S2 and S3. Data are expressed in mmol/L for total FAs concentration, or molar percentage of total lipids and are represented as mean ± SEM of separate extractions and quantifications from the twelve mixes (six summer and six winter serum mixes, except for EPA with data from only three summer and three winter mixes). Paired Student t-test were used to compare wummer and winter data and Benjamini-Hochberg correction was applied for multiple comparisons. * indicates BH adjusted p value < 0.05 when comparing seasons, ** for p < 0.01, *** for p < 0.001, NS: non significant. AA:arachidonic acid, ALA: alpha-linolenic acid, DHA: docosahexaenoic acid, DPA: docosapentaenoic acid, EPA: eicosapentaenoic acid, LA: linoleic acid, OA: oleic acid, PA: palmitic acid, SA: stearic acid, SBS: summer bear serum, WBS: winter bear serum