Fig. 4
From: Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax
Reorganization of lipid metabolism in the tail during metamorphic climax. a Heatmap showing the variation of fatty acids during natural metamorphosis; #, p < 0.05 (one-way ANOVA). b FFAs and acylcarnitines differed in content between control and T3-treated groups; *, p < 0.05. c–d Transcriptional changes of genes involved in lipid metabolism after T3-treatment; *, p < 0.05. e Network denotes adjustments on lipid metabolism in the tail. f FFA derivatives/bioactive lipids varied in content (p < 0.05, one-way ANOVA) during natural metamorphosis (PG, prostaglandin; HETE, hydroperoxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid). Different letters denote significant differences between groups (p < 0.05), as determined by the Student–Newman–Keuls post hoc test after one-way ANOVA. g Transcriptional changes of critical enzymes involved in prostaglandin and leukotrienes biosynthesis. *, p < 0.05; **, p < 0.01. (H) Differently expressed cytochrome P450 genes involved in arachidonic acid metabolism (p < 0.05). (I) Network denotes the upregulated synthesis of FFA derivatives