Drug | N (tissue/animal) | Tone before (mN) | Tone after (mN) | p value | EFS contractile on before (mN) | EFS contractile on after (mN) | p value |
---|---|---|---|---|---|---|---|
Ach | 12/8 | 8.3 [5.2/11.8] | 9.2 [7.5/12.8] | 0.002 | Â | Â | Â |
Atropine | 12/10 | 12.3 [4.6/18.6] | 11.7 [4.1/19.2] | 0.42 | 2.1 [1.0/8.8] | 0.8 [0.1/2.1] | 0.008 |
L-NAME | 10/7 | 11.9 [9.7/22.5] | 12.7 [11.0/21.9] | 0.049 | 0.9 [0.3/2.6] | 3.6 [2.4/7.3] | 0.004 |
SNP | 11/7 | 17.2 [5.8/19.9] | 4.9 [3.7/14.3] | < 0.001 |  |  |  |
5-HT | 7/4 | 5.9 [3.8/8.2] | 4.3 [3.5/5.4] | 0.109 | Â | Â | Â |
Dopamine | 7/4 | 11.5 [7.4/12.4] | 10.8 [6.9/12.0] | 0.69 | Â | Â | Â |
Domperidone | 6/3 | 12.1 [10.6/13.2] | 12.4 [10.6/13.6] | 0.438 | 1.5 [1.1/4.2] | 2.1 [1.6/3.9] | 0.438 |
VIP | 7/4 | 10.3 [8.4/15.6] | 8.3 [7.1/14.5] | 0.036 | Â | Â | Â |
Suramin | 10/5 | 10.3 [5.9/13.5] | 9.7 [4.8/12.6] | 0.084 | 0.4 [0.1/1.2] | 0.4 [0.1/1.7] | 0.461 |
Propranolol | 8/6 | 9.1 [7.4/10.3] | 8.9 [7.3/10.4] | 0.938 | 0.1 [0.0/1.2] | 0.1 [0.0/1.5] | 0.5 |
Isoproterenol | 11/7 | 10.9 [8.8/14.3] | 8.7 [6.0/10.0] | 0.002 | 1.7 [0.9/4.4] | 0.3 [0.2/2.0] | 0.027 |
TTX | 11/6 | 6.2 [4.0/13.1] | 6.3 [4.5/12.8] | 0.898 | 1.4 [0.4/5.0] | 1.9 [0.8/3.6] | 1 |
Lidocaine | 14/7 | 6.5 [3.9/10.3] | 17.5 [7.6/21.1] | < 0.001 | 2.6 [1.3/5.7] | 0.0 [0.0/0.8] | 0.002 |
Na-free Krebs sol | 7/4 | 9.6 [6.7/10.4] | 21.0 [16.8/23.0] | 0.016 | 1.8 [0.5/3.8] | 0.0 [0.0/0.3] | 0.008 |