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Table 2 The effect of different drugs on the motility of the proximal stomach

From: Enteric neuroanatomy and smooth muscle activity in the western diamondback rattlesnake (Crotalus atrox)

Drug

N (tissue/animal)

Tone Before (mN)

Tone After (mN)

p value

EFS contractile on before (mN)

EFS contractile on after (mN)

p value

Ach

9/5

8.9 [6.8/16.1]

11.8 [9.1/27.3]

0.047

   

Atropine

11/6

10.4 [8.1/20.9]

9.4 [6.3/20.2]

0.52

7.4 [1.9/18.0]

0.6 [-0.1/5.4]

0.039

L-NAME

6/5

6.3 [5.0/7.4]

7.4 [6.5/19.5]

0.031

9.1 [1.6/15.5]

14.4 [3.2/25.2]

0.007

SNP

5/3

24.3 [14.5/41.8]

3.6 [2.1/6.1]

0.021

   

5-HT

8/4

5.4 [3.6/8.2]

14.5 [11.0/15.8]

0.006

   

Dopamine

7/5

6.0 [4.7/9.1]

4.7 [3.6/9.6]

0.375

   

Domperidone

7/4

15.3 [10.7/22.3]

11.9 [9.1/17.3]

0.156

10.6 [6.2/16.3]

12.1 [2.8/16.3]

0.668

VIP

7/5

16.0 [6.3/17.7]

6.9 [4.0/15.0]

0.014

   

Suramin

9/5

7.6 [7.4/17.6]

7.3 [3.0/18.1]

0.461

16.7 [8.4/22.1]

17.7 [8.7/27.5]

0.148

Propranolol

8/5

6.3 [3.3/7.3]

7.9 [3.9/16.8]

0.148

8.9 [4.6/19.3]

23.3 [17.5/39.2]

0.004

Isoproterenol

8/6

9.8 [5.5/12.6]

3.3 [1.8/6.9]

0.008

13.0 [6.7/17.7]

2.6 [1.6/4.9]

0.012

TTX

6/4

5.6 [5.0/22.6]

5.9 [4.4/18.7]

0.313

13.2 [9.1/21.6]

12.7 [7.1/20.1]

0.563

Lidocaine

8/6

6.8 [5.1/12.9]

21.6 [19.8/31.9]

< 0.001

9.3 [6.1/17.6]

0.0 [-0.7/0.4]

0.008

Na-free Krebs sol

7/4

12.5 [10.4/15.0]

74.9 [70.9/90.6]

0.016

16.4 [4.3/19.5]

0.0 [0.0/0.0]

0.016

  1. Changes in the muscle tone and of the response to EFS after the application of different drugs. Bold letters mean a significant effect