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Fig. 6 | Frontiers in Zoology

Fig. 6

From: Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)

Fig. 6

Age and seasonal changes in DNA methylation and sirt1 expression in gilthead sea bream muscle. Site-specific DNA methylation (%) of sirt1 in white skeletal muscle in winter (a) and summer (b) of fish of different ages (+ 3, three-year-old; + 1, one-year-old). Data are the mean ± SEM of 8–10 fish. CpG position with a circle indicates significant differences between ages by t-test (P < 0.05). Dashed lines indicate the mean methylation of all individuals and positions. (c) Correlation between DNA methylation at CpG3 in the sirt1 gene promoter region and sirt1 gene expression in white skeletal muscle (WSM) of gilthead sea bream during summer. Green and red points represent data from + 3, three-year-old and + 1, one-year-old fish, respectively

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