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Fig. 2 | Frontiers in Zoology

Fig. 2

From: Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)

Fig. 2

CpG islands and regulatory elements in sirt1 of gilthead sea bream. a Schematic representation of the CpG islands (CGIs) in sirt1 of gilthead sea bream (in blue). Yellow lines represent CpG sites. Numbers indicate the position of the putative transcription start site (TSS, black arrow) and the starting and ending point of the first exon (red box) and intron (red line) with respect to the start codon (ATG, red). b Regulatory elements in sirt1 of gilthead sea bream. The first intron sequence was replaced by an indication of their length. Lower case letters indicate a 2-kb sequence upstream of the translational start site ATG and include the 5′ UTR and the 5′ flanking region. The predicted core promoter region is flanked by brackets. The putative TSS is shaded in black. Predicted regulatory elements are indicated in bold, underlined, and lower case italics. CGI is shaded in gray. The analyzed CpG positions are shaded in red. This CGI spans the first exon and expands into the first intron (not shown)

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Frontiers in Zoology

ISSN: 1742-9994