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Table 1 Effects of treatment on potential biomarkers

From: Repeated stressors in adulthood increase the rate of biological ageing

  Effect of treatment Effect of time Interaction treatment*time
Genome-wide telomere length (bp) p > 0.28 F (1,32) = 28.81, p < 0.0005 F (1,32) = 11.47, p = 0.002
Plasma oxidative damage (mM H2O2 equivalents) p > 0.2 F (1,30.99) = 42.46, p < 0.0005 F (1, 30.99) = 6.84, p = 0.014
Plasma non-enzymatic antioxidants (mM HOCl neutralized) p > 0.1 F (1,29.75) = 8.49, p = 0.007 p > 0.3
Glutathione peroxidase (U/l hemolysate) p > 0.1 F (1,30.71) = 64.54, p < 0.0005 p > 0.26
Scaled mass index p > 0.12 F(1,32) = 3.65, p = 0.065 p > 0.7
Locomotor activity (hops/min.) F (1,32) = 5.18, p = 0.03 p > 0.1 F (1,32) = 21.84, p < 0.0005
Baseline corticosterone (ng/ml) p > 0.7 p > 0.3 p > 0.5
Stress-induced corticosterone (ng/ml) p > 0.3 p > 0.4 p > 0.8
Difference between stress-induced corticosterone and concentrations after dexamethasone injection (ng/ml) p > 0.1 p > 0.6 p > 0.7
Corticosterone after ACTH injection (ng/ml) p > 0.5 p > 0.09 p > 0.6
  1. Effects of stress-exposure (repeated LPS injections and 10-day chronic disturbance protocols combined) on potential biomarkers (all log-transformed) assessed at the beginning and the end of the experiment, as determined from LMM statistics (for details see text). Significant effects are highlighted in bold. Data are shown in Figure 2.