Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

Table 1 Results of mixed model showing the effect of reproductive status (successful vs. unsuccessful) and reproductive period (before or during reproduction) on plasmatic oxidative damage (d-ROMs) and plasmatic antioxidant defences (OXY) levels in female mice

d-ROMs	Random Effects	Estimate	SE
	Constant	2.24	0.93
	Individual	1.37	0.42
	Fixed Effects	Estimate	SE	F1,21	P value
	Intercept	9.97	0.48
	Reproductive Status	−1.48	0.96	0.10	0.753
	Reproductive Period	−2.72	0.39	13.17	0.002
	Status × Period	2.1	0.84	8.25	0.009
OXY	Random Effects	Estimate	SE
	Constant	187.9	124.5
	Individual	351	108.3
	Fixed Effects	Estimate	SE	F1,21	P value
	Intercept	226	5.47
	Reproductive Status	−0.49	11.74	0.14	0.716
	Reproductive Period	−17.94	6.25	4.31	0.050
	Status × Period	8.08	13.4	0.36	0.553

Significant terms are reported in boldface. Non-significant interactions were backward dropped from the model. Residuals of the models follow a normal distribution, all Kolmogorov-Smirnov tests, P > 0.79.

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