Overview of eicosanoid biosynthesis based on current knowledge from mammalian models. The three major pathways, cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 epoxygenase, are shown displaying major metabolites. Prostanoids cover prostaglandins (PG) and thromboxane (TX), while leukotrienes (LT) include LTs and lipoxins. PGD2 and PGE2 may be transformed into PGJ2 and PGA2 through either non-enzymatic rearrangement or dehydration, respectively. Abbreviations: EET, epoxyeicosatrienoic acids; HETE, hydroxyeicosatetraenoic acids; HPETE, hydroperoxyeicosatetraenoic acids. Diagram modified from Stanley  and KEGG .