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Figure 4 | Frontiers in Zoology

Figure 4

From: The exceptional stem cell system of Macrostomum lignano: Screening for gene expression and studying cell proliferation by hydroxyurea treatment and irradiation

Figure 4

Influence of irradiation on the stem cell population as shown by BrdU-incorporation in M. lignano. (A) Confocal projection of labeled S-phase cells in non treated control animal after 30 minutes BrdU-pulse. Note bilaterial distribution of BrdU cells and clusters in testes (t) and ovaries (o). (B) Confocal projection of labeled S-phase cells after one week recovering from 80 Gy irradiation. BrdU labeled cells can be found only in gonads. (C) Confocal projection after 3 weeks recovering from irradiation, BrdU incorporation was comparable with control. (D) Effect of irradiation on mitoses. Note the dramatic reduction in the number of mitoses 3 hours and 1 day postirradiation and the recovery of cell proliferation after 7 and 21 days. scalebar 100 μm.

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Frontiers in Zoology

ISSN: 1742-9994