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Table 2 Number of MHC class II DRB exon 2 alleles (ca. 200 bp) and sequence diversity in free-ranging vertebrate populations investigated in their natural environment. In addition, for comparison of variability levels of species with a low number of MHC alleles two studies of captive-bred populations are included. * DRB-locus is duplicated. N = sample size.

From: The importance of immune gene variability (MHC) in evolutionary ecology and conservation

Species Order Country Nr of alleles (N) Nr (%) of variable nucleotide positions Nr (%) of variable amino acid positions Nr (%) of amino acid differences between alleles References
Microcebus murinus primates Madagascar 14 (228) 71 (41.5) 31 (54.4) 5 (8.8) – 25 (43.9) [110,174]
Microcebus berthae primates Madagascar 9 (42) 46 (26.9) 24 (42.1) 3 (5.3) – 19 (33.3) Sommer et al., unpublished data
Apodemus sylvaticus rodentia Germany 38 (119) 71 (32.7) 38 (52.8) 2 (2.7) – 28 (38.8) [206]
Apodemus flavicollis rodentia Germany 27 (146) 49 (22.6) 28 (38.9) 1 (1.4) – 21 (29.2) [173]
Leopoldamys sabanus rodentia Borneo 28* (49) 85 (49.7) 39 (68.4) 4 (7.0) – 25 (43.9) Lenz et al., unpublished data
Gerbillurus paeba rodentia South Africa 34* (40) 68 (39.8) 33 (57.9) 1 (1.8) – 19 (33.3) [172]
Rhabdomys pumilio rodentia South Africa 20 (58) 43 (25.1) 23 (40.4) 1 (1.8) – 14 (24.6) [163]
Rattus rattus rodentia Madagascar 13 (58) 72 (40.7) 33 (55.9) 3 (5.1) – 26 (44.1) Sommer, unpublished data
Hypogeomys antimena rodentia Madagascar 5 (229) 37 (17.1) 19 (26.4) 6 (8.3) – 21 (29.2) [201]
Equus przewalskii perissodactyla captive-bred 6* (14) 52 (20.8) 29 (34.9) 1 (1.2) – 22 (26.5) [55]
Oryx leucoryx artiodactyla captive-bred 3 (57) 35 (14.8) 21 (26.9) 13 (16.7) – 17 (21.8) [129]
Damaliscus pygargus pygargus artiodactyla South Africa 6 (45) 21 (8.4) 14 (16.9) 1 (1.2) – 13 (15.7) [130]