Figure 5

Tertiary structures of tick salivary lipocalins. Panel A displays the crystal structure of the tick lipocalin OmCI from O. moubata (; PDB: 3ZUO) and four predicted tertiary structures from the tick toxins, namely TSGP2, TSGP3, TSGP4 from O. savignyi and moubatin, also from O. moubata (respective UniProt: Q8I9U1, Q8I9U0, Q8I9T9 and Q04669). The tertiary structures depict the conserved disulfide bridges (indicated by roman numerals), loops, β-sheets that forms the β-hairpin, and the α-helix. All structures are colored from the N-terminus (blue) to the C-terminus (red). Below each tertiary structure is the respective electrostatic potential in 180° turns (blue = positive; red = negative; white = neutral). A tertiary structural alignment in Panel B depicts the Cα protein backbone (color codes for each structure is presented on the right). All structures have <2.2 Å root mean square deviation compared with OmCI.