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Figure 5 | Frontiers in Zoology

Figure 5

From: New developmental evidence supports a homeotic frameshift of digit identity in the evolution of the bird wing

Figure 5

Results of single injections at HH18 and their fate at control and cyclopamine-treated HH31 wings. Asides from the triple injection shown in Figure 4, we performed numerous single injections that confirm an experimental homeotic frameshift is induced by inhibition of Shh signalling. (a) In control embryos, labelled cells near the limit between somites 17/18 developed into digit A (blue, n = 11). Labelled cells near the limit between somites 18/19 were allocated to digit B (green and brown, n = 16). Labelled cells near the limit between somites 19/20 formed digit C (red and purple, n = 30). (b) In cyclopamine-treated embryos, labelled cells near the limit between somites 17/18 allocated anterior to the cartilage of any digit (blue, n = 5). Labelled cells near the limit between somites 18/19 were allocated to a digit A (green, n = 10). Labelled cells between somites 19/20 develops into digit B (red and purple, n = 26).

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