Figure 6
An age conversion model for O. latipes (in months) and human (in years): Age medaka = 0.0954 × Age human + 0.0171 × Age human 2. Three major hallmarks: sexual maturation, median life expectancy and up-to-date record of maximum lifespan were used for regression. Red circles ○ represent data from the present study: sexual maturation (O. latipes : ca. 3 month-old; human: 12-15 year-old), median life expectancy (O. latipes : ♂ = 13.7 | ♀ = 14.6 months; human: world’s average ♂ = 65.7 | ♀ = 70.1 years) and up-to-date record of maximum lifespan (O. latipes : ♂ = 32.0 | ♀ = 39.5 months; human: ♂ Jiroemon Kimura = 116.1 | ♀ Jeanne Calment = 122.4 years). According to the regression curve (R2 = 0.996), the occurrence of estrogen decline in the female medaka (between 8 to 12 month-old) in our culture could be interpolated to human age of 46.0 to 60.4 year-old, which is akin to “menopause” in women. Previous aging data from [66] (blue cross +) and [54] (green triangle △) were overlaid for reference.