Change of plasma sex hormones level in male (blue) and female (pink) O. latipes during aging (top: estrogen; middle: testosterone; bottom: 11-keto-testosterone). Normalized hormone levels are denoted by the bar length and the colored mark on the opposite side of the origin. Error bars are standard error of mean (SEM). Bars annotated with different letters are significantly different. Statistical significant difference between the two sexes was detected for all three sex hormones at all age groups (all FDR-adjusted p < 0.05).