Drug | N (tissue/animal) | Tone Before (mN) | Tone After (mN) | p value | EFS contractile on before (mN) | EFS contractile on after (mN) | p value |
---|---|---|---|---|---|---|---|
Ach | 9/5 | 8.9 [6.8/16.1] | 11.8 [9.1/27.3] | 0.047 | Â | Â | Â |
Atropine | 11/6 | 10.4 [8.1/20.9] | 9.4 [6.3/20.2] | 0.52 | 7.4 [1.9/18.0] | 0.6 [-0.1/5.4] | 0.039 |
L-NAME | 6/5 | 6.3 [5.0/7.4] | 7.4 [6.5/19.5] | 0.031 | 9.1 [1.6/15.5] | 14.4 [3.2/25.2] | 0.007 |
SNP | 5/3 | 24.3 [14.5/41.8] | 3.6 [2.1/6.1] | 0.021 | Â | Â | Â |
5-HT | 8/4 | 5.4 [3.6/8.2] | 14.5 [11.0/15.8] | 0.006 | Â | Â | Â |
Dopamine | 7/5 | 6.0 [4.7/9.1] | 4.7 [3.6/9.6] | 0.375 | Â | Â | Â |
Domperidone | 7/4 | 15.3 [10.7/22.3] | 11.9 [9.1/17.3] | 0.156 | 10.6 [6.2/16.3] | 12.1 [2.8/16.3] | 0.668 |
VIP | 7/5 | 16.0 [6.3/17.7] | 6.9 [4.0/15.0] | 0.014 | Â | Â | Â |
Suramin | 9/5 | 7.6 [7.4/17.6] | 7.3 [3.0/18.1] | 0.461 | 16.7 [8.4/22.1] | 17.7 [8.7/27.5] | 0.148 |
Propranolol | 8/5 | 6.3 [3.3/7.3] | 7.9 [3.9/16.8] | 0.148 | 8.9 [4.6/19.3] | 23.3 [17.5/39.2] | 0.004 |
Isoproterenol | 8/6 | 9.8 [5.5/12.6] | 3.3 [1.8/6.9] | 0.008 | 13.0 [6.7/17.7] | 2.6 [1.6/4.9] | 0.012 |
TTX | 6/4 | 5.6 [5.0/22.6] | 5.9 [4.4/18.7] | 0.313 | 13.2 [9.1/21.6] | 12.7 [7.1/20.1] | 0.563 |
Lidocaine | 8/6 | 6.8 [5.1/12.9] | 21.6 [19.8/31.9] | < 0.001 | 9.3 [6.1/17.6] | 0.0 [-0.7/0.4] | 0.008 |
Na-free Krebs sol | 7/4 | 12.5 [10.4/15.0] | 74.9 [70.9/90.6] | 0.016 | 16.4 [4.3/19.5] | 0.0 [0.0/0.0] | 0.016 |