Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

Table 2 Analyses of covariance on relationships between pre (1) and post-reproductive (2) d-ROMs and OXY plasma levels and litter size at birth and at weaning in female mice

Litter size at birth	Pre-reproductive values	df	Estimate	SE	Khi2	P-value
	Intercept		8.08	2.21
	d-ROMs(1)	1,17	−0.37	0.17	4.25	0.039
	OXY(1)	1,17	0.01	0.01	0.65	0.419
	Post-reproductive values
	Intercept		6.04	3.62
	d-ROMs (2)	1,17	−0.08	0.16	−0.51	0.621
	OXY(2)	1,17	0.01	0.011	0.55	0.588
Litter size at weaning	Pre-reproductive values
	Intercept		6.27	4.36
	d-ROMs(1)	1,17	0.05	0.33	0.14	0.893
	OXY(1)	1,17	−0.01	0.02	−0.40	0.694
	Post-reproductive values
	Intercept		0.60	4.30
	d-ROMs (2)	1,17	0.59	0.19	7.44	0.006
	OXY(2)	1,17	−0.01	0.02	0.13	0.716

Significant terms are reported in boldface. Residuals of each model follow a normal distribution, all Kolmogorov-Smirnov tests, P > 0.62.

ISSN: 1742-9994